PROGRAM

THURSDAY, May 21, 2020
8:30 - 8:45Welcome remarksICMN2020 Organizing Committee and the BrightFocus Foundation
8:45 - 10:25Session I: Glial Contributions to Neurodegeneration Chair: Guojun Bu
Mayo Clinic FL, USA
8:45 - 9:10The roles of genes and innate immunity in Alzheimer’s diseaseRudolph Tanzi
Mass General Hospital/Harvard Med School, USA
9:10 - 9:35 Genetic studies of Alzheimer’s disease implicate microglia in risk for diseaseAlison Goate
Icahn School of Medicine at Mount Sinai, USA
9:35 - 10:00A neuropathological perspective on neuroinflammation and microglia in Alzheimer’s disease Jeroen Hoozemans
VUmc, The Netherlands
10:00 - 10:25MAOists join BAPtists and TAUists in Alzheimer research: Reactive Astrocytes, MAO-B, GABA, H2O2, as a cause of Alzheimer’s diseaseC. Justin Lee
Institute for Basic Science, Korea
10:25 - 10:45Coffee break/Exhibits
10:45 - 12:25Session II: Functional Studies of GliaChair: Robert Vassar
Northwestern University, USA
10:45 - 11:10 An astrocyte-microglia lipid signaling pathway in Alzheimer’s diseaseHui Zheng
Baylor College of Medicine, USA
11:10 - 11:35 Pathways involving microglia and apoE in neurodegeneration David Holtzman
Washington University School of Medicine in St Louis, USA
11:35 - 12:00 Multiomic landscape and functional analysis of Alzheimer’s disease-associated gene variants in human ESC-derived microgliaHuaxi Xu
Sanford Burnham Prebys Medical Discovery Institute, USA
12:00 - 12:25Immune-inflammatory modulation as a therapeutic strategy
for neurodegenerative diseases
Seung Hyun Kim
Hanyang University, South Korea
12:25 - 13:45Lunch/Exhibits
13:45 - 15:25Session III: Novel Systems and Approaches Chair: Riqiang Yan
University of Connecticut, USA
13:45 - 14:10Using chimeric models to examine the impact of AD risk genes on human microglial functionMathew Blurton-Jones
University of California, Irvine, USA
14:10 - 14:35Modulation of amyloid deposition and neuroinflammation by the microbiomeSangram Sisodia
University of Chicago, USA
14:35 - 15:00White matter mechanisms in neurodegenerationFrancesca-Fang Liao
The University of Tennessee Health Science Center, USA
15:00 - 15:25Mossy cell synaptic degeneration causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer’s diseaseYouming Lu
Tongji Medical School, Huazhong University of Science and Technology, China
15:25 - 15:45Coffee break/Exhibits
15:45 - 17:15Short Talk I
Six short talks of 15 min each (12 min + 3 min Q&A) to be selected from submitted abstracts
Chair: Henrietta Nielsen
Stockholm University, Sweden
17:15 - 18:00Panel Discussion I: Glial Contributions to Neurodegeneration
18:15 - 20:00Poster Session 1 and Welcome Reception
FRIDAY, May 22, 2020
8:30 - 10:10Session IV: ApoE and Vascular Contributions to NeurodegenerationChair: Hui Zheng
Baylor College of Medicine, USA
8:30 - 8:55Impact of vascular apoE isoforms on brain cognition and Alzheimer-related pathology Guojun Bu
Mayo Clinic Jacksonville, USA
8:55 - 9:20New insights into the role of lipoproteins in Alzheimer’s disease Cheryl Wellington
University of British Columbia, Canada
9:20 - 9:45Relevance of a liver APOE4 phenotype and plasma apolipoprotein E levels to pathological processes in the brain Henrietta Nielsen
Stockholm University, Sweden
9:45 - 10:10Role of vasculature and glia in the pathogenesis of glaucoma, a leading neurodegenerative diseaseAbbot Clark
University of North Texas Health Science Center, USA
10:10 - 10:30Coffee break/Exhibits
10:30 - 12:35Session V: Pathogenic Mechanisms of Neurodegeneration (AD and ADRD)Chair: Sangram Sisodia
Northwestern University, USA
10:30 - 10:55The role of angiotensin converting enzyme in Alzheimer’s disease pathogenesis Robert Vassar
Northwestern University, USA
10:55 - 11:20Tau protein & Tau pathology: Structure, aggregation, and spreadingEckard Mandelkow
DZNE, Germany
11:20 - 11:45DJ-1 regulates the integrity and function of ER-mitochondria association: Implications in Parkinson’s diseaseXiongwei Zhu
Case Western Reserve University, USA
11:45 - 12:10Enhancing neurogenesis by CX3CL1 back signals reverses neuronal loss and reduces amyloid deposition in AD mouse modelsRiqiang Yan
University of Connecticut, USA
12:10 - 12:35Neuronal and non-neuronal functions of Alzheimer’s disease GWAS risk factor BIN1Gopal Thinakaran
USF Morsani College of Medicine, USA
12:35 - 14:00Lunch/Exhibits
Meet the Editors
14:00 - 15:40Session VI: Pathogenic Mechanisms of Neurodegeneration (PD and ALS)Chair: Gopal Thinakaran
USF Morsani College of Medicine, USA
14:00 - 14:25Multiscale gene network analysis identifies novel pathways and key regulators of Parkinson’s diseaseBin Zhang
Icahn School of Medicine at Mount Sinai, USA
14:25 - 14:50 Mitochondrial and lysosomal dysfunction in Parkinson's disease: therapeutic implications in human neuronsDimitri Krainc
Northwestern University, USA
14:50 - 15:15 Understanding the mechanistic link between C9orf72 and TDP-43Leonard Petrucelli
Mayo Clinic, USA
15:15 - 15:40Targeting TDP-43 splicing repression for neurodegenerative diseasePhilip Wong
Johns Hopkins University, USA
15:40 - 16:00Coffee break/Exhibits
16:00 - 17:30Short Talk II
Six short talks of 15 min each (12 min + 3 min Q&A) to be selected from submitted abstracts
Chair: Hongmei Li
Mayo Clinic, USA
17:30 - 18:15Panel Discussion II: Vascular Contributions to Neurodegeneration
18:15 - 20:00Poster Session 2
SATURDAY, May 23, 2020
8:30 - 10:10Session VII: Neuropathology and Clinical InsightsChair: TBA
8:30 - 8:55The molecular origins of Alzheimer’s disease: when does it start and what strategies for primary prevention?Colin Masters
Florey Institute, Australia
8:55 - 9:20Neuropathology of common age-related neurodegenerative disordersDennis Dickson
Mayo Clinic, USA
9:20 - 9:45Endosomal cargo sorting dysfunction in Alzheimer's disease pathogenesis: therapeutic implications
Domenico Pratico
Temple University, USA
9:45 - 10:10Targeting Aβ protofibrils with BAN2401 - from mutation to potential therapy for ADLars Lannfelt
Uppsala University, Sweden
10:10 - 10:30Coffee break/Exhibits
10:30 - 12:15Session VIII: Therapeutic ApproachesChair: Huaxi Xu
Sanford Burnham Prebys Medical Discovery Institute, USA
10:30 - 10:55Cell and animal models of tau pathology, modes of toxicity, and therapeutic approachesEva Mandelkow
DZNE, Germany
10:55 - 11:20TREM2: from a loss-of-function to a novel target for disease modulation?Christian Haass
LMU/DZNE, Germany
11:20 - 11:45Therapeutic strategies targeting alpha-synuclein in AD-related dementiaPamela McLean
Mayo Clinic, USA
11:45 - 12:00BrightFocus Foundation Travel Fellowship Award Ceremony Diane Bovenkamp and Keith Whitaker
BrightFocus Foundation, USA
12:00 - 12:15Short talk/poster awards and closing remarks
12:15 - 13:00Lunch and Networking